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Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent.
Pindiprolu, Sai Kiran S S; Kumar, Chirravuri S Phani; Kumar Golla, Venu Sampath; P, Likitha; K, Shreyas Chandra; S K, Esub Basha; R K, Ramachandra.
Med Hypotheses ; 143: 109858, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-631831

ABSTRACT

Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2. In this hypothesis, we discuss the potential of pulmonary delivery of SAL using nanostructured lipid carriers (NLCs) against SARS-CoV-2.


Subject(s)
Antiviral Agents/administration & dosage , Coronavirus Infections/drug therapy , Drug Carriers , Lipids/chemistry , Nanostructures/chemistry , Pneumonia, Viral/drug therapy , Pyrans/administration & dosage , Betacoronavirus , COVID-19 , Drug Repositioning , Endocytosis , Humans , Lung/drug effects , Pandemics , RNA, Viral , SARS-CoV-2 , COVID-19 Drug Treatment
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